Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

What is Genetic Engineering?

What is Genetic Engineering?

Plant Breeding and Biotechnology

Plant Breeding and Biotechnology

Crop cultivation has a long history in human civilization, with records showing the cultivation of cereal plants beginning at around 8000 BC. This early plant breeding was developed primarily to provide a steady supply of food.

Transgenic Organisms

Transgenic Organisms

Bioremediation

Bioremediation

Bioremediation is the use of prokaryotes, fungi, or plants to remove pollutants from the environment. This process has been used to remove harmful toxins in groundwater as a byproduct of agricultural run-off and also to clean up oil spills.

Recombinant DNA

Recombinant DNA

Transgenic Plants

Transgenic Plants

Recombinant DNA technology called transgenesis is often used to add a foreign gene or remove a detrimental gene from an organism. Such genetically modified organisms are called transgenic organisms.
The first-ever transgenic plant was a tobacco plant developed in 1983 that showed resistance against the tobacco mosaic virus. Since then, many transgenic plants have been developed and commercialized for improving the agricultural, ornamental, and horticultural value of a crop plant. Transgenic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Resilience of recombinant antibiotic resistance gene-containing plasmids against common cell culture disposal methods.

Cell reports methods·2026

Same author

Genetic Markers Remain Detectable in Genetically Engineered Microbes Biocontained with a CRISPR Kill Switch.

Environmental science & technology·2026

Same author

Elucidating biodegradation of dimethyl terephthalate by two <i>Rhodococcus</i> strains for its valorization applications.

Metabolic engineering communications·2026

Same author

Elucidation of odd-chain dicarboxylate metabolism in Acinetobacter baylyi and application to polyethylene upcycling.

Trends in biotechnology·2026

Same author

Engineering microbial consortia for mixed plastic upcycling.

Nature communications·2025

Same author

Conditional guide RNA deactivation by mRNA and small molecule triggers in Saccharomyces cerevisiae.

New biotechnology·2025

Same journal

Silicone oil in protein drug products and its implications for formulation stability.

Advanced drug delivery reviews·2026

Same journal

Targeted delivery of proteolysis-targeting chimeras (PROTAC) and molecular glue degraders (MGD).

Advanced drug delivery reviews·2026

Same journal

Lysosome-targeting degrader delivery system: from formulation design to biomedical applications.

Advanced drug delivery reviews·2026

Same journal

Anti-PEG antibodies in nanomedicine: Mechanisms, risks, and opportunities.

Advanced drug delivery reviews·2026

Same journal

Optimizing macrophage-targeted intracellular delivery systems for safe and effective immunotherapies.

Advanced drug delivery reviews·2026

Same journal

Light-controlled CRISPR-dCas9 epigenome editing: advanced drug-delivery strategies and oncology applications.

Advanced drug delivery reviews·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 14, 2025

Author Spotlight: Discovering New Biopesticides from Bioactive Soil Microbe-Derived Natural Products

Author Spotlight: Discovering New Biopesticides from Bioactive Soil Microbe-Derived Natural Products

Published on: July 26, 2024

Be a GEM: Biocontained, environmentally applied, genetically engineered microbes.

Tae Seok Moon¹

¹Synthetic Biology Group, J. Craig Venter Institute, La Jolla, CA, United States.

Advanced Drug Delivery Reviews

|April 13, 2025

Summary

This summary is machine-generated.

Genetically engineered microbes (GEMs) offer applications in diagnostics and therapeutics. Addressing biocontainment, environmental, regulatory, and public perception challenges is crucial for realizing their full potential.

Keywords:

Biocontainment GMO regulation Genetic circuit Genetically engineered microbe Genetically modified organism Probiotic Public perception

More Related Videos

Isolation of Soil Microorganisms Using iChip Technology

Isolation of Soil Microorganisms Using iChip Technology

Published on: January 10, 2025

Mass Production of Entomopathogenic Fungi, Metarhizium robertsii and Metarhizium pinghaense, for Commercial Application Against Insect Pests

Mass Production of Entomopathogenic Fungi, Metarhizium robertsii and Metarhizium pinghaense, for Commercial Application Against Insect Pests

Published on: March 31, 2022

Related Experiment Videos

Last Updated: May 14, 2025

Author Spotlight: Discovering New Biopesticides from Bioactive Soil Microbe-Derived Natural Products

Author Spotlight: Discovering New Biopesticides from Bioactive Soil Microbe-Derived Natural Products

Published on: July 26, 2024

Isolation of Soil Microorganisms Using iChip Technology

Isolation of Soil Microorganisms Using iChip Technology

Published on: January 10, 2025

Mass Production of Entomopathogenic Fungi, Metarhizium robertsii and Metarhizium pinghaense, for Commercial Application Against Insect Pests

Mass Production of Entomopathogenic Fungi, Metarhizium robertsii and Metarhizium pinghaense, for Commercial Application Against Insect Pests

Published on: March 31, 2022

Area of Science:

Engineering biology
Synthetic biology
Microbial biotechnology

Background:

Technological advancements have enabled practical applications of genetically engineered microbes (GEMs).
GEMs show promise as living diagnostics and therapeutic delivery vehicles.
Significant technological and non-technological hurdles remain for GEMs.

Purpose of the Study:

To discuss technologies for genetically engineered microbe (GEM) biocontainment.
To explore environmental impacts, regulatory issues, and public perception of GEMs.

Main Methods:

This perspective discusses existing and emerging biocontainment technologies.
It reviews environmental risks associated with GEM deployment.
It examines the regulatory landscape and public attitudes towards GEMs.

Main Results:

Biocontainment technologies are advancing but require further development.
Environmental and regulatory frameworks need to mature alongside technological progress.
Public perception significantly influences the acceptance and implementation of GEMs.

Conclusions:

Realizing the full potential of GEMs requires a holistic approach.
Addressing biocontainment, environmental, regulatory, and public concerns is essential.
Integrated strategies are needed for the safe and effective deployment of GEMs.