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Updated: May 13, 2025

Brain Death Induction in Mice Using Intra-Arterial Blood Pressure Monitoring and Ventilation via Tracheostomy

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[Brain Death/Death by Neurologic Criteria: Guidelines and Recent Developments].

Masao Nagayama¹

¹Department of Neurology, International University of Health and Welfare (IUHW) Graduate School of Medicine / Narita Hospital.

Brain and Nerve = Shinkei Kenkyu No Shinpo

|April 13, 2025

Summary

Brain death/death by neurologic criteria (BD/DNC) involves irreversible cessation of all brain functions. Recent guidelines standardize BD/DNC determination globally for adults and children.

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SECONDs Administration Guidelines: A Fast Tool to Assess Consciousness in Brain-injured Patients

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Published on: February 6, 2021

Area of Science:

Neurology
Critical Care Medicine

Background:

Brain death/death by neurologic criteria (BD/DNC) defines the irreversible cessation of all brain functions.
Massive organic brain damage is the cause of BD/DNC.

Purpose of the Study:

To review current concepts and practices of BD/DNC determination.
To highlight recent developments in BD/DNC guidelines worldwide and in Japan.

Main Methods:

Review of international guidelines, including the 2020 World Brain Death Project.
Integration of updated 2023 guidelines for adults and pediatric populations.
Analysis of BD/DNC practices in Japan and globally.

Main Results:

The World Brain Death Project (2020) standardized BD/DNC criteria internationally.
Updated guidelines in 2023 integrated adult and pediatric recommendations.
Current review covers global and Japanese practices in BD/DNC determination.

Conclusions:

Standardized guidelines are crucial for accurate BD/DNC determination.
Recent updates reflect an integrated approach for all age groups.
Ongoing review of practices ensures adherence to evolving diagnostic criteria.