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Published on: October 4, 2021
Levodopa and nutrition support: A case report of Parkinsonism-hyperpyrexia syndrome
Ryan Burslem1, Liz Ramos2, Chou Chou3
1Department of Clinical Nutrition, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, USA.
Abstract:
Levodopa is competitively inhibited by amino acids for absorption across the intestinal wall and blood-brain barrier. An acute withdrawal of levodopa increases the risk of Parkinsonism-hyperpyrexia syndrome, a life-threatening condition characterized by muscular rigidity, mental status changes, hyperthermia, and autonomic instability. This report discusses the case of a patient with Parkinson's disease who was critically ill who developed Parkinsonism-hyperpyrexia syndrome while receiving enteral and parenteral nutrition support. Clinicians should be aware of this potential drug-nutrient interaction when prescribing nutrition support to patients taking levodopa.
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