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Factors Affecting Continuation of Aripiprazole Long-acting Injection in the Real World
Soyeon Chang1, Seri Maeng1, Yangsik Kim1
1Department of Psychiatry, Inha University Hospital, Inha University College of Medicine, Incheon, Korea.
Summary
Aripiprazole long-acting injection (LAI) discontinuation in Korea was 27.9% within one year, primarily due to efficacy, side effects, or preference for oral forms. Patient compliance significantly impacts continuation rates.
Area of Science:
- Psychiatry
- Pharmacology
- Clinical Pharmacy
Background:
- Aripiprazole long-acting injection (LAI) is a key treatment for psychiatric disorders.
- Factors influencing aripiprazole LAI continuation in the Korean population remain understudied.
- Understanding these factors is crucial for optimizing patient outcomes.
Purpose of the Study:
- To identify real-world factors affecting the continuation of aripiprazole LAI in Korean patients.
- To analyze discontinuation rates and reasons for aripiprazole LAI use.
- To provide insights for improving LAI treatment adherence.
Main Methods:
- A 1-year retrospective cohort study of 68 patients initiating aripiprazole LAI.
- Review of patient medical records to assess continuation, duration, and discontinuation reasons.
- Statistical analysis including univariate and multiple logistic regression.
Main Results:
- The 12-month discontinuation rate for aripiprazole LAI was 27.9%.
- Primary discontinuation reasons included insufficient efficacy (42.1%), adverse effects (31.6%), and preference for oral medication (21.1%).
- Patient compliance and transitioning from paliperidone LAI were associated with aripiprazole LAI continuation.
Conclusions:
- Aripiprazole LAI demonstrates clinical effectiveness with a lower one-year discontinuation rate compared to paliperidone LAI.
- Patient compliance is a significant factor influencing aripiprazole LAI continuation.
- Further large-scale, prospective studies are needed to confirm these findings.
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