Deactivation Mechanism and Mitigation Strategies of Single-Atom Site Electrocatalysts

Single-atom site electrocatalysts (SACs), with maximum atom efficiency, fine-tuned coordination structure, and exceptional reactivity toward catalysis, energy, and environmental purification, have become the emerging frontier in recent decade. Along with significant breakthroughs in activity and selectivity, the limited stability and durability of SACs are often underemphasized, posing a grand challenge in meeting the practical requirements. One pivotal obstacle to the construction of highly stable SACs is the heavy reliance on empirical rather than rational design methods. A comprehensive review is urgently needed to offer a concise overview of the recent progress in SACs stability/durability, encompassing both deactivation mechanism and mitigation strategies. Herein, this review first critically summarizes the SACs degradation mechanism and induction factors at the atomic-, meso- and nanoscale, mainly based on but not limited to oxygen reduction reaction. Subsequently, potential stability/durability improvement strategies by tuning catalyst composition, structure, morphology and surface are delineated, including construction of robust substrate and metal-support interaction, optimization of active site stability, fabrication of porosity and surface modification. Finally, the challenges and prospects for robust SACs are discussed. This review facilitates the fundamental understanding of catalyst degradation mechanism and provides efficient design principles aimed at overcoming deactivation difficulties for SACs and beyond.