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Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

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Pathway Complexity of Kinetically Trapped Dipeptide-Based Metastable State: Supramolecular Structural Transformation

Soumen Kuila¹, Souvik Misra¹, Tukai Singha²

¹Department of Chemistry, University of North Bengal, Raja Rammohanpur, Siliguri, West Bengal, 734013, India.

Small (Weinheim an Der Bergstrasse, Germany)

|April 14, 2025

Summary

Kinetic control of supramolecular polymerization in naphthalimide-conjugated dipeptides allows precise material property tuning. This study demonstrates controlling nanostructure formation and stability by modulating solvent composition for targeted applications.

Keywords:

helicity inversion metastable state pathway complexity phase transition self‐assembly solvent composition

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Area of Science:

Supramolecular chemistry
Materials science
Nanotechnology

Background:

Supramolecular polymerization complexity requires kinetic control for material property tuning.
Naphthalimide-conjugated dipeptides offer tunable self-assembly pathways.
Understanding nanostructure formation is key to controlling material properties.

Purpose of the Study:

To investigate the pathway complexity and structural transformation of a naphthalimide-conjugated dipeptide.
To explore kinetic control over supramolecular polymerization using a binary solvent system.
To modulate self-assembly and nanostructure formation by altering water percentage.

Main Methods:

Spectroscopic and microscopic investigations.
Controlled self-assembly in DMSO-water mixtures.
Analysis of kinetic vs. thermodynamic stability.

Main Results:

Self-assembly transitions from monomer to helical nanofibrils.
Kinetically trapped gel states achieved at lower water percentages.
Helicity modulation and thermoreversible chiral memory observed.

Conclusions:

Kinetic control is crucial for managing supramolecular polymerization pathways.
Water percentage in binary solvents effectively controls self-assembly kinetics and nanostructure.
The system exhibits tunable properties and chiral memory, offering potential for advanced materials.