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[Evaluation of VEGF-A, SP-D and MUC-1 expression in poisoning with baclofen and its combination with ethanol]
O L Romanova1,2, M L Blagonravov1, P G Dzhuvalyakov1,2
1Peoples' Friendship University of Russia named after Patrice Lumumba, Moscow, Russia.
Objective:
To detect MUC-1, VEGF-A, SP-D expression in lungs of rats at different times after the administration of baclofen and its combination with ethanol.
Results:
An increased MUC-1 expression has been noted in presence of the administration of baclofen and its combination with ethanol. MUC-1 caused an enhancement of VEGF-A expression under hypoxia, that has been also observed in all experimental groups. SP-D expression was increased in all experimental groups.
Conclusions:
Understanding of the processes that occur in lungs of animals in administration of baclofen and its combination with ethanol is necessary to develop effective treatment measures for cases of non-fatal poisoning in human by this substance, and it will be useful in determining the immediate cause of death in the case of fatal poisoning.
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