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Association between P53 Gene Mutations and Colorectal Cancer in the Iranian Population: A Systematic Review
Nima Nikbin Kavishahi1, Javad Yaghmoorian Khojini2, Mehrazin Khamespanah Duruh3
1Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Iranian Journal of Public Health
|April 14, 2025
Summary
Mutations in the P53 gene, particularly the Arg allele at codon 72, may increase colorectal cancer (CRC) risk and metastasis in Iran. P53 gene mutations in exons 5-8 are linked to poor CRC prognosis.
Area of Science:
- Oncology
- Genetics
- Cancer Research
Background:
- Colorectal cancer (CRC) is a significant health concern in Iran.
- The P53 gene plays a crucial role in cancer development and progression.
Purpose of the Study:
- To systematically review the association between P53 gene mutations and CRC in the Iranian population.
- To identify specific P53 gene alterations linked to CRC susceptibility and prognosis.
Main Methods:
- A comprehensive literature search was performed across six major databases.
- Included studies focused on P53 gene mutations and CRC in Iran, published in English or Persian.
- A total of 17 relevant articles were selected from 313 initial records.
Main Results:
- Six case-control studies examined the P53 codon 72 polymorphism, with three finding significant genotype frequency differences in CRC patients.
- Exon 6 emerged as a frequently mutated site in CRC.
- G to A mutations at CpG sites within exons 5-8 were the most common type, and exon 7 mutations correlated with poorer prognosis.
Conclusions:
- The Arg allele at P53 codon 72 may be associated with increased susceptibility to CRC development and metastasis in Iranians.
- Mutations in P53 exons 5-8 are potential indicators of poor prognosis in colorectal cancer.
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