Investigating the antimicrobial activity of 1-heteroaryl benzotriazole silver compounds
Ahmed Elzein1, Ghadah Abdullah S Al Jomeh1, Graham J Tizzard2
1Department of Chemistry, School of Life Sciences, University of Sussex Brighton BN1 9QJ UK G.Kostakis@sussex.ac.uk.
Abstract:
Five (1-5) Ag(i) compounds, derived from different N,N'-bidentate 1-heteroaryl benzotriazole ligands, were synthesised and characterised using SXRD, IR, UV-Vis, elemental analysis, ESI-MS, and NMR. Variations in ligands and counter-anions produced distinct structures and morphologies. Preliminary antimicrobial testing at the micromolar level, in DMSO, revealed that only compound 2, based on 1-(2-pyridyl)benzotriazole and triflate anion, exhibited interesting antimicrobial properties, thus marking the introduction of a new class of Ag(i) compounds in medicinal inorganic chemistry.
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