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An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy
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Lactylation in CNS disorders: mechanisms, cellular function, and disease relevance
Jiaxin Tian1, Tongyu Zhang2, Ruidan Zhang3
1Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
Frontiers in Cell and Developmental Biology
|April 14, 2025
Summary
Lactylation, a novel protein modification, uses lactate to regulate cell functions and gene expression. This review explores lactylation
Area of Science:
- Biochemistry and Molecular Biology
- Neuroscience
- Epigenetics
Background:
- Lactate is a key metabolic substrate in the central nervous system (CNS).
- Emerging multi-omics technologies reveal lactate's novel role beyond energy metabolism.
- Lactylation, a post-translational modification (PTM), involves lactate attachment to proteins.
Purpose of the Study:
- To review the key enzymes ('Writers,' 'Erasers,' 'Readers') regulating lactylation.
- To categorize lactylation in different CNS cell types.
- To investigate lactylation's roles in neurological diseases like neurodegeneration, brain tumors, and injuries.
Main Methods:
- Comprehensive literature review of recent research on lactylation.
- Analysis of multi-omics data integrating metabolic and epigenetic information.
- Systematic categorization of lactylation's involvement in CNS pathologies.
Main Results:
- Lactylation precisely regulates protein function and gene expression.
- A dynamic network of enzymes and metabolic pathways controls lactylation.
- Lactylation is implicated in the pathogenesis of neurodegenerative diseases, brain tumors, and injuries.
Conclusions:
- Lactylation represents a significant PTM with broad implications in CNS physiology and pathology.
- Understanding lactylation mechanisms is crucial for advancing research in neurological disorders.
- Further research into lactylation holds potential for novel therapeutic strategies in brain diseases.
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