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Updated: May 13, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Visible Light-Promoted Defluorinative Alkylation of Trifluoromethyl Ketones with α-Aminoalkyl Boron Species
Yue Zhang1,2, Kun Li1,2, Zhihong Wang1,2
1State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, People's Republic of China.
Abstract:
In this study, we developed a photoredox-catalyzed defluorinative cross-coupling method for trifluoroketones and alkyl boronic acids. The reaction afforded a series of novel α,α-difluoroketone derivatives, and in vitro fungicidal activity revealed that some of these compounds exhibited moderate to excellent activity against Rhizoctonia solani and Botrytis cinerea. In particular, compound 3d showed an EC50 value of 4.27 μg/mL against B. cinerea and can be used as a fungicidal lead compound for further optimization.
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