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Lifestyle factors play a critical role in maintaining overall health and preventing chronic diseases. Key elements, such as regular physical activity, a nutritious diet, and abstinence from smoking, can significantly enhance physical, mental, and emotional well-being while reducing the risk of several life-threatening conditions.
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Related Experiment Video

Updated: May 13, 2025

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
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Beyond Genetics: Exploring Lifestyle, Microbiome, and Social Determinants in Oral Cancer Development.

Anil Menon1, Vimi S Mutalik2, Yongqiang Chen3

  • 1Department of Preventive Dental Sciences, Dr. Gerald Niznick College of Dentistry, University of Manitoba, Winnipeg, MB R3E 0W2, Canada.

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Summary

This review explores how lifestyle, oral microbiome, and socioeconomic factors interact to influence oral cancer progression. Understanding these combined effects is crucial for developing better prevention and treatment strategies.

Keywords:
coffeedietfishlifestylemicrobiomemouthoral canceroral squamous cell carcinomasocioeconomic statustea

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Area of Science:

  • Oncology
  • Public Health
  • Microbiology

Background:

  • Oral cancer is a significant global health concern, ranking as the 16th most prevalent cancer and sixth leading cause of cancer mortality.
  • Current understanding of oral cancer progression mechanisms and early diagnostic interventions requires improvement.
  • Existing reviews often focus on individual risk factors, neglecting their combined impact on oral cancer.

Purpose of the Study:

  • To review the combinational effects of lifestyle habits, oral microbiome, and socioeconomic factors on oral cancer progression.
  • To highlight the interplay between these extracellular factors in the context of oral cancer.
  • To provide an updated overview for researchers on factors influencing oral cancer.

Main Methods:

  • Literature review synthesizing existing research on oral cancer.
  • Focused analysis on the interplay of lifestyle, oral microbiome, and socioeconomic status.
  • Evaluation of how these factors individually and collectively impact oral cancer development and progression.

Main Results:

  • Lifestyle factors like diet (high-sugar, processed foods, alcohol, smoking) promote oral cancer, while others (fruits, vegetables, tea, coffee, exercise) may combat it.
  • The oral microbiome can either suppress or promote oral cancer progression.
  • Low socioeconomic status is linked to increased oral cancer risk, and interactions between these factors significantly influence outcomes.

Conclusions:

  • The combined influence of lifestyle, oral microbiome, and socioeconomic status is critical in oral cancer progression.
  • Further research should prioritize investigating these multifactorial interactions for improved oral cancer prevention and treatment.
  • This review underscores the need for integrated approaches addressing these interconnected factors.