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Published on: June 28, 2024
Electrochemiluminescence imaging for immunoassay of prostate-specific antigen utilizing AIE-active polymer dots as
Hang Gao1, Jia-Yuan Zhu1, Lingling Xu1
1School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China. gaohang@yzu.edu.cn.
Abstract:
We report, for the first time to the best of our knowledge, an electrochemiluminescent (ECL) immunosensor for the imaging analysis of prostate-specific antigen, using aggregation-induced-emission-active polymer dots (Pdots) as emitters. Assisted by rolling circle amplification, the immunosensor exhibits high sensitivity, with a low detection limit of 4.2 pg mL-1. This work demonstrates the potential of AIE-active Pdots in clinical applications.
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