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Topical treatment modalities in pressure ulcers: a retrospective analysis
Pinar Oztas1, Emine Karabulut Demirci2, F Nur Baran Aksakal3
1MD, Professor, Lokman Hekim University Faculty of Medicine, Department of Dermatology, Ankara, Turkey.
Journal of Wound Care
|April 14, 2025
Summary
Effective pressure ulcer (PU) treatment requires focusing on suspected deep tissue injury (SDTI) cases and ensuring adequate hospitalisation duration. Multilayer silicone foam dressings proved most effective for PU healing.
Area of Science:
- Wound healing research
- Dermatology
- Geriatric care
Background:
- Pressure ulcers (PUs) are localized tissue damage from sustained pressure, friction, or shear.
- Effective prevention and treatment are crucial for patient outcomes.
- Topical therapies are key treatment options once PUs develop.
Purpose of the Study:
- To retrospectively investigate the effectiveness of various topical therapeutic alternatives for pressure ulcers.
- To identify factors influencing PU treatment success.
Main Methods:
- Retrospective single-centre study of hospitalised patients with stage 2 or deeper PUs.
- Data collected included patient demographics, PU stage, hospitalisation duration, and therapies used.
- Treatment success was defined as any evidence of healing by discharge.
Main Results:
- 55.4% of patients showed no healing by discharge.
- Higher therapy success rates were observed in suspected deep tissue injury (SDTI) PUs (59.4%).
- Longer hospitalisation (>30 days) correlated with increased therapy success. Multilayer silicone foam dressing was the most effective topical therapy, while rifamycin and povidone-iodine worsened PU conditions.
Conclusions:
- Topical PU therapy is more effective in SDTIs and with sufficient treatment duration.
- Multilayer silicone foam dressings are the most effective topical treatment for pressure ulcers.
- Certain topical agents like rifamycin and povidone-iodine may impede PU healing.
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