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Related Experiment Video

Updated: May 13, 2025

Neuronavigation-guided Repetitive Transcranial Magnetic Stimulation for Aphasia
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Sequential Navigated Multilocus Repetitive Transcranial Magnetic Stimulation for Concurrent Somatic and Psychiatric

Satu K Jääskeläinen1, Mi Tram1, Tero Taiminen2

  • 1From the Division of Medical Imaging, Department of Clinical Neurophysiology, Turku University Hospital and University of Turku.

The Journal of ECT
|April 14, 2025
PubMed
Summary
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Successful suppression of musical hallucinations with low-frequency rTMS of the left temporo-parietal junction: A case report.

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Incidence of and Characteristics Associated With Long-term Benzodiazepine Use in Finland.

JAMA network open·2020

Multilocus repetitive transcranial magnetic stimulation (rTMS) effectively treated patients with multiple neurological and psychiatric disorders. High response rates suggest rTMS is a viable option for complex comorbid conditions.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Technology

Background:

  • Repetitive transcranial magnetic stimulation (rTMS) is recognized for treating neurological and psychiatric conditions.
  • Comorbid disorders often present complex treatment challenges.
  • Investigating multilocus rTMS for patients with multiple concurrent conditions is crucial.

Purpose of the Study:

  • To assess the efficacy and feasibility of using multilocus rTMS in patients with more than one coexisting disorder.
  • To determine response rates and overall treatment effectiveness in a comorbid patient population.

Main Methods:

  • A retrospective study of 31 patients (19 women, 12 men) with comorbid chronic pain, depression, tinnitus, anxiety, OCD, or eating disorders.
  • Utilized an E-field navigated TMS device for a 10-day rTMS trial with varied cortical targets.
Keywords:
major depressionmultilocus stimulationpainrepetitive transcranial magnetic stimulationtinnitus

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  • Response defined as at least a 30% decrease in disorder-specific scale severity, assessed at baseline and post-treatment.
  • Main Results:

    • An 84% response rate was observed for at least one condition treated with multilocus rTMS.
    • 19 patients responded to treatment for both indications, while 7 responded for a single indication.
    • Global Impression of Change was positive in 85% of patients (n=20).

    Conclusions:

    • Multilocus rTMS demonstrates significant efficiency in managing comorbid neurological and psychiatric disorders.
    • The high responder rate in patients with comorbidities suggests potential patient-related factors influencing rTMS efficacy.
    • No serious adverse effects were reported, indicating a favorable safety profile.