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PTEN Regulates Myofibroblast Activation in Valvular Interstitial Cells Based on Subcellular Localization

Dilara Batan1,2, Georgios Tseropoulos1,2, Bruce E Kirkpatrick1,2,3

  • 1Department of Chemical and Biological Engineering, University of Colorado, Boulder, Colorado, 80303, USA.

Advanced Biology
|April 15, 2025
PubMed
Summary

The tumor suppressor PTEN (phosphatase and tensin homolog) protects against aortic valve stenosis (AVS) by preventing valvular interstitial cell activation. PTEN promotes a quiescent fibroblast phenotype, offering a potential therapeutic target for AVS.

Keywords:
fibrosisheart valvehydrogelsinterstitial cells

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