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Role of antidiarrheal agents nifuroxazide in antitumor multi‑target anticancer, multi‑mechanism anticancer drug

Liping Liu1, Chengshan Ma2, Jinfeng Ji1

  • 1Oncology Department, Qingdao Endocrine and Diabetes Hospital, Qingdao, Shandong 266000, P.R. China.

Oncology Letters
|April 15, 2025
PubMed

Insights

Nifuroxazide (NFZ), an antimicrobial, shows promise as an antitumor agent by inhibiting STAT3 and inflammatory pathways. Its diverse mechanisms and safety profile support its potential clinical use in cancer treatment.

Area of Science:

  • Oncology
  • Pharmacology
  • Immunology

Background:

  • Nifuroxazide (NFZ) is an established antimicrobial agent.
  • Recent research highlights NFZ's potential as an antitumor agent.
  • NFZ exhibits multifaceted anti-tumor activities beyond its antimicrobial properties.

Purpose of the Study:

  • To review and elucidate the diverse anti-tumor mechanisms of Nifuroxazide (NFZ).
  • To provide a comprehensive reference for future research and clinical implementation of NFZ in cancer therapy.

Main Methods:

  • Literature review of studies investigating Nifuroxazide's anti-tumor effects.
  • Analysis of NFZ's molecular targets and pathways involved in cancer.
  • Evaluation of NFZ's impact on the tumor microenvironment and immune response.

Main Results:

  • NFZ acts as a STAT3 inhibitor and modulates IL-6, impacting inflammatory pathways.
  • NFZ targets aldehyde dehydrogenase 1 and ubiquitin-specific protease 21.
  • NFZ inhibits tumor angiogenesis and migration, enhances anti-tumor immunity, and increases cancer cell cytotoxicity.
  • NFZ demonstrates synergistic effects with other anti-cancer drugs and possesses a favorable safety profile.

Conclusions:

  • Nifuroxazide (NFZ) presents a promising, safe, and effective multi-targeted agent for cancer treatment.
  • Understanding NFZ's comprehensive anti-tumor mechanisms is crucial for its clinical translation.
  • NFZ holds potential for integration into various cancer therapy strategies.
Keywords:
ALDHERGIL-6STAT3nifuroxazidetumortumor microenvironment

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