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An Exploratory Study of Factors Associated with Medication Adherence in Chinese Rheumatoid Arthritis Patients
Mang He1,2, Yan-Juan Chen1, Lu Huang3
1Department of Rheumatology and Immunology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, People's Republic of China.
Journal of Inflammation Research
|April 15, 2025
Summary
Medication adherence in Chinese rheumatoid arthritis (RA) patients was 61.57%. Patient satisfaction significantly improved adherence, highlighting its importance for treatment success and quality of life.
Area of Science:
- Rheumatology
- Clinical Pharmacy
- Health Services Research
Background:
- Rheumatoid arthritis (RA) management requires consistent medication adherence for optimal outcomes.
- Understanding adherence prevalence and influencing factors in specific populations, like Chinese RA patients, is crucial.
Purpose of the Study:
- To determine the prevalence of medication adherence among Chinese patients with RA.
- To identify sociodemographic, clinical, and patient-reported factors associated with medication adherence in this cohort.
Main Methods:
- A cross-sectional study involving 1137 RA patients in Guizhou, China.
- Data collection included sociodemographics, adherence, satisfaction, quality of life (QoL), disease course, and comorbidities.
- Multifactorial logistic regression and mediation analysis were used to identify influencing factors and relationships.
Main Results:
- Good medication adherence was observed in 61.57% of RA patients.
- Patient satisfaction (OR=2.079), treatment regimen (OR=0.280), and pulmonary infection (OR=1.695) were independently associated with adherence.
- Higher QoL was noted in patients with good adherence and satisfaction; adherence mediated the link between satisfaction and mental health.
Conclusions:
- Patient satisfaction is a key factor positively associated with medication adherence in Chinese RA patients.
- Enhancing patient satisfaction may be a viable strategy to improve medication adherence and subsequently patient outcomes.
- Limitations include single-center design and potential unmeasured confounders, warranting cautious interpretation and further research.
