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Updated: May 13, 2025

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
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Visible Light-Promoted Three-Component Reaction for the Synthesis of Pyrrolopyrazoles
Han-Peng Pan1, Shao-Shuai Chen1, Han Yang1
1School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, P. R. China.
Abstract:
A visible light-enabled three-component cascade assembles pyrrolopyrazoles from arylalkynes, benzoquinones, and 5-aminopyrazole through a mechanistically validated carbonyl-alkyne metathesis/(3 + 2)-cycloaddition/1,2-aryl migration sequence. This protocol delivers pyrrolopyrazole heterocycles in up to 96% yield with excellent functional group tolerance. Preliminary biological screening identified promising antitumor activity in selected products, highlighting the potential value of this method. The proposed reaction mechanism is supported by control experiments.
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