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Related Concept Videos

Electroconvulsive Therapy01:30

Electroconvulsive Therapy

18
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
18

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Remote Ischemic Preconditioning Does Not Alleviate Post-Electroconvulsive Therapy Cognitive Dysfunction.

Ravitej Bhat1, Venkatapura J Ramesh2, Jagadisha Thirthalli3

  • 1From the Department of Anaesthesiology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal.

The Journal of ECT
|April 15, 2025
PubMed
Summary
This summary is machine-generated.

Remote ischemic preconditioning (RIPC) did not reduce cognitive dysfunction after electroconvulsive therapy (ECT) in schizophrenia patients. RIPC was found to be safe and feasible during ECT.

Keywords:
RIPCcognitionelectroconvulsive therapyschizophrenia

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Clinical Trials

Background:

  • Electroconvulsive therapy (ECT) is used for severe mental illnesses.
  • Cognitive dysfunction is a common side effect of ECT.
  • Remote ischemic preconditioning (RIPC) is being investigated for neuroprotective effects.

Purpose of the Study:

  • To evaluate the efficacy of RIPC in mitigating cognitive deficits following ECT in schizophrenia patients.
  • To assess the safety and feasibility of RIPC in this patient population.

Main Methods:

  • A randomized controlled trial was conducted.
  • Patients with schizophrenia received either RIPC or sham RIPC before each of six ECT sessions.
  • Cognitive and memory functions were assessed using standardized scales (HMSE, B4ECT ReCoDe, PGI, CGI-SI).

Main Results:

  • No significant differences were observed in cognitive or memory assessments between the RIPC and sham RIPC groups.
  • Sociodemographic and clinical characteristics were similar across both groups.
  • The intervention showed no statistically significant impact on cognitive dysfunction post-ECT.

Conclusions:

  • RIPC was not effective in reducing post-ECT cognitive dysfunction in schizophrenia patients.
  • RIPC was demonstrated to be safe and feasible in patients undergoing ECT.
  • The intervention did not adversely affect the primary psychiatric condition.