Ruthenium-Catalyzed Site-Selective Annulation of Benzoxazinones: An Easy Access to Dihydroisoquinoline Benzamide
Subir Panja1, Biprajit Paul1, Anay Saha2
1School of Chemical Science, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, 700032, India.
Abstract:
A ruthenium-catalyzed chelation-assisted substrate-controlled, site-selective, one-pot three-component cascade dehydrogenative annulation reaction is reported here. The developed methodology leads to the synthesis of biologically active 4H-benzo[d] [1,3] oxazin-4-one derivatives by the nucleophilic addition of amines to benzoxazinones followed by coupling with diphenyl acetylenes. In addition to providing excellent yields of products, the method is also regioselective. This new protocol has been demonstrated to have an easy access to a variety of dihydroisoquinoline benzamide derivatives.
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