Enhanced detection of autism spectrum disorder through neuroimaging data using stack classifier ensembled with...

BackgroundAutism spectrum disorder (ASD) is a neurodevelopmental disease marked by a variety of repetitive behaviors and social communication difficulties.PurposeTo develop a generalizable machine learning (ML) classifier that can accurately and effectively predict ASD in children.Material and MethodsThis paper makes use of neuroimaging data from the Autism Brain Imaging Data Exchange (ABIDE I and II) datasets through a combination of structural and functional magnetic resonance imaging data. Several ML models, such as Support Vector Machines (SVM), CatBoost, random forest (RF), and stack classifiers, were tested to demonstrate which model performs the best in ASD classification when used alongside a deep convolutional neural network.ResultsResults showed that stack classifier performed the best among the models, with the highest accuracy of 81.68%, sensitivity of 85.08%, and specificity of 79.13% for ABIDE I, and 81.34%, 83.61%, and 82.21% for ABIDE II, showing its superior ability to identify complex patterns in neuroimaging data. SVM performed poorly across all metrics, showing its limitations in dealing with high-dimensional neuroimaging data.ConclusionThe results show that the application of ML models, especially ensemble approaches like stack classifier, holds significant promise in improving the accuracy with which ASD is detected using neuroimaging and thus shows their potential for use in clinical applications and early intervention strategies.