Related Experiment Video
Updated: Jun 29, 2026
Right Ventricular Systolic Pressure Measurements in Combination with Harvest of Lung and Immune Tissue Samples in Mice
Published on: January 16, 2013
Circulating Intercellular Adhesion Molecule as a Novel Marker of Pulmonary Hypertension in Newborn
Antoine Fakhry AbdelMassih1,2, Sherif ElAnwary3, Nourhan Taha4
1Pediatric Cardiology Unit, Pediatric Cardiology Division, Department of Pediatrics, Faculty of Medicine, Cairo University Children Hospital, Cairo University, Kasr Al Ainy Street, Cairo, 12411, Egypt. antoine.abdelmassih@kasralainy.edu.eg.
Background:
IntercellularAQ1 adhesion molecules (ICAMs) are released from the endothelium in response to shear stress. Their role in persistent pulmonary hypertension (PPHN) remains un-investigated.
Methodology:
Sixty neonates (30 PPHN, 30 controls) underwent serum ICAM testing and echocardiography.
Results:
Right and left ventricular function was depressed in PPHN cases. Tricuspid annular plane systolic excursion was reduced (Cases 8±1 vs. Controls 11±3.5). ICAM was elevated in cases (332±96 vs. 208 ±36).
Conclusion:
ICAM is a sensitive PPHN marker. Elevated ICAM may result from endothelial damage or contribute to PPHN pathogenesis. Further studies are needed to confirm these results and explore this relationship.
