Related Experiment Video

Updated: Sep 10, 2025

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
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High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

Published on: July 9, 2010

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Myocardial dysfunction is linked to endothelial dysfunction in JIA patients: a study of novel aortic circumferential

Eman Shafik Shafie1, Fatma ElZahraa Mostafa2, Mohamad Samir AbdelWanis3

  • 1Department of Pediatrics, Pediatric Rheumatology Unit, Cairo University Children Hospital, Cairo University, Cairo, Egypt.

Pediatric Rheumatology Online Journal
|August 25, 2025
PubMed

Insights

Juvenile idiopathic arthritis (JIA) is linked to impaired vascular and heart function. This study found a correlation between vascular stiffness and myocardial dysfunction in JIA patients, suggesting inflammation plays a key role.

Area of Science:

  • Cardiology
  • Rheumatology
  • Vascular Biology

Background:

  • Juvenile idiopathic arthritis (JIA) is associated with accelerated vascular stiffness and myocardial dysfunction.
  • The direct relationship between vascular and myocardial impairment in JIA is not well-understood.

Purpose of the Study:

  • To investigate the correlation between vascular and myocardial function in patients with JIA.

Main Methods:

  • Compared 22 JIA patients with 22 controls.
  • Assessed vascular function using flow-mediated dilation (FMD) and aortic circumferential strain (ACS).
  • Evaluated left ventricular function via 3D speckle tracking echocardiography and global longitudinal strain (GLS).
  • Measured inflammation using the JADAS-10 score.

Main Results:

  • JIA patients showed impaired ACS and FMD compared to controls.
  • Global longitudinal strain (GLS) was significantly reduced in JIA patients.
  • A significant correlation was found between ACS and GLS.
  • Impaired vascular relaxibility correlated with higher JADAS scores, indicating inflammation's negative impact.

Conclusions:

  • This study supports the link between vascular involvement and myocardial dysfunction in JIA.
  • Findings suggest low-grade inflammation contributes to cardiovascular disease in JIA.
  • Further molecular-level research with larger cohorts is needed to confirm these mechanisms.
Abstract

Keywords:
ACS: Aortic circumferential strainJIA: Juvenile idiopathic arthritisSTE: Speckle tracking echocardiography

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