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Related Experiment Video

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A cross-sectional multicentre study of multishell diffusion MRI in multiple sclerosis.

Einar A Høgestøl1, Daniel A Rinker2, Ivan Maximov3

  • 1Department of Neurology, Oslo University Hospital, Oslo, Norway; Department of Psychology, University of Oslo, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Multiple Sclerosis and Related Disorders
|April 15, 2025
PubMed
Summary
This summary is machine-generated.

Advanced diffusion MRI reveals white matter differences in multiple sclerosis (MS) patients compared to healthy controls. However, only some advanced metrics correlated with disability, and these links were not significant after correction.

Keywords:
Diffusion weighted imagingMRIMulticentreMultiple sclerosis

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Area of Science:

  • Neuroimaging
  • Medical Physics
  • Radiology

Background:

  • White matter (WM) microstructural changes in multiple sclerosis (MS) are linked to clinical disability.
  • Advanced multishell diffusion MRI (dMRI) offers detailed WM property assessment.

Purpose of the Study:

  • To compute WM metrics using multishell dMRI.
  • To identify differences in WM metrics between people with MS (pwMS) and healthy controls (HCs).
  • To investigate associations between WM metrics and clinical disability (EDSS).

Main Methods:

  • Multishell dMRI data from 251 pwMS/clinically isolated syndrome (CIS) and 543 HCs were analyzed.
  • Eleven scalar metric maps were derived using diffusion tensor imaging (DTI) and restriction spectrum imaging (RSI).
  • Tract-based spatial statistics (TBSS) and linear regression models were used to test for group differences and correlations with Expanded Disability Status Scale (EDSS).

Main Results:

  • Significant group differences were observed in nine out of eleven dMRI metrics.
  • Linear regression showed correlations between EDSS and fractional anisotropy (FA) fast, and apparent diffusion coefficient (ADC) fast.
  • These correlations lost statistical significance after Bonferroni correction.

Conclusions:

  • Clinically feasible multishell dMRI can detect WM differences between pwMS and HCs.
  • Only a subset of advanced multishell parameters were sensitive to disability.
  • No statistically significant correlations between dMRI metrics and disability remained after correction.