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Updated: May 13, 2025

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
Published on: June 15, 2019
Coacervation-responsive cubosome containing hyaluronic acid and albumin complex
Hyeon Ki Son1, Panalee Pomseethong1, Jin-Chul Kim1
1Department of Biomedical Science & Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Republic of Korea.
Abstract:
Coacervation-responsive cubosomes were prepared by loading a complex of hydrophobically modified hyaluronic acid (HmHA) and hydrophobically modified albumin (HmAlb) and steviol glycoside (SG) into the water channels. Hyaluronic acid and albumin were modified with a lipid chain, and the HmHA and HmAlb were characterized by 1H NMR and FT-IR spectroscopy, respectively. The formation of the HmHA/HmAlb coacervate complex was optimized when the mass ratio was 1:9 under pH 4.0 conditions. The phase transition temperature of the cubic phase complex was observed to increase slightly from 60.9°C to 61.6°C as a result of the inclusion of the coacervate complex, as evidenced by differential scanning calorimetry. The maximum release degree of SG at 22°C was suppressed to 30.9% due to the coacervate at pH 3, and it was promoted to 75.9% at pH 5.5 due to the dissolution of the electrostatic complex as the pH value increased. The monoolein of the cubosDome enhanced the in vitro skin permeation of the cubosomal SG, as it could play a role as a skin permeation enhancer. The coacervation-responsive cubosome could be potentially used as a drug carrier that can release its content in a pH-controlled manner.
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