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A pilot study on SMILE-derived lenticule patch implantation: stromal augmentation for various corneal pathologies
Burak Mergen1, Ali Ceylan1, Fahri Onur Aydin1
1University of Health Sciences, Basaksehir Cam and Sakura City Hospital, Department of Ophthalmology, Istanbul, Turkey.
Summary
Small-incision lenticule extraction (SMILE)-derived lenticule patch grafts effectively preserve corneal integrity for various defects. This method offers a reliable alternative, especially when immediate cornea transplantation is not feasible.
Area of Science:
- Ophthalmology
- Corneal Surgery
- Biomaterials
Background:
- Corneal defects pose significant challenges to vision and ocular health.
- Traditional management options may have limitations or be unavailable.
- Small-incision lenticule extraction (SMILE) offers a source of biological material for corneal repair.
Purpose of the Study:
- To evaluate the initial clinical outcomes of using SMILE-derived lenticule patch grafts for corneal defect management.
- To assess the efficacy and safety of this novel approach in restoring corneal integrity and visual acuity.
Main Methods:
- Retrospective evaluation of 16 patients who received SMILE-derived lenticule patch grafts.
- Analysis of graft etiology, best corrected visual acuity (BCVA), and globe integrity.
- 1-year follow-up to record outcomes and secondary interventions.
Main Results:
- Anatomic success (corneal integrity) was achieved in all 16 eyes.
- Mean BCVA improved from 1.9 to 1.2 logMAR.
- Common etiologies included neurotrophic keratitis, penetrating injuries, and inflammatory disorders.
Conclusions:
- SMILE-derived lenticule patch grafts are effective and reliable for managing corneal defects.
- This technique preserves eye integrity and serves as a valuable alternative to corneal transplantation.
- It is particularly useful for patients awaiting donor tissue or unable to undergo immediate transplantation.
