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Triterpenoids from Ganoderma cochlear against inflammation and renal fibrosis
Jian-Biao Zhang1, Sheng-Hong Li1, Zhi-Yuan Li2
1School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China; Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics, Marshall Laboratory of Biomedical Engineering, Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, PR China.
Abstract:
Seven new triterpenoids, fornicatins N - T (1-7), were isolated from Ganoderma cochlear. Their structures including absolute configurations were determined by 1D and 2D nuclear magnetic resonance (NMR) spectroscopy, computational methods, and HRESIMS. The structures of compounds 1, 3, and 6 were also characterized by X-ray crystallographic analysis. In particular, compound 1 features a 6/4/6/5 tetracyclic triterpenoid skeleton. The biological activities of compounds 1-7 were evaluated using Western blot and CCK-8 assays. It was found that compound 6 exhibited significant anti-renal fibrosis activity, while compounds 3, 4, and 6 demonstrated notable anti-inflammatory activity.
