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Feasibility of an Individualized Exercise Training Program for Children with Hypertrophic Cardiomyopathy
Julianne Wanner1,2, Danielle Burstein1,3, Stephen Paridon1
1Division of Cardiology, The Children'S Hospital of Philadelphia, Philadelphia, PA, USA.
Pediatric Cardiology
|April 15, 2025
Summary
This pilot study suggests a moderate-intensity exercise program may be safe and beneficial for children with hypertrophic cardiomyopathy (HCM). Improvements in exercise capacity and quality of life were observed in participants who completed the program.
Area of Science:
- Pediatric Cardiology
- Exercise Physiology
- Clinical Trials
Background:
- Limited data guide exercise recommendations for pediatric hypertrophic cardiomyopathy (HCM).
- Traditional restrictions on exercise in pediatric HCM contrast with adult findings of cardiovascular and psychological benefits.
- This study addresses the need for evidence on exercise safety and feasibility in this population.
Purpose of the Study:
- To assess the safety and feasibility of a moderate-intensity exercise program for pediatric HCM patients.
- To gather data for designing future, larger-scale studies on exercise interventions in pediatric HCM.
- To evaluate the impact of exercise on cardiorespiratory fitness and quality of life in children with HCM.
Main Methods:
- Recruited eight pediatric HCM patients (ages 8-18), NYHA Class I/II.
- Implemented a 16-week program: 3 aerobic and 2 strength sessions/week.
- Utilized cardiopulmonary exercise testing (CPET) for target heart rate and FitBit for activity titration.
Main Results:
- Four completers showed improved exercise performance and Health-Related Quality of Life (HRQoL).
- No intervention-related arrhythmias or cardiac adverse events were reported.
- Baseline cardiorespiratory fitness and HRQoL were lower than peers.
Conclusions:
- A moderate-intensity exercise program shows promise for pediatric HCM patients.
- The program appears safe, with potential benefits for fitness and quality of life.
- Future research should focus on improving adherence and further evaluating exercise impacts.
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