Triangular Lunulae in Papillon-Lefèvre Syndrome: A Case Report.

Area of Science:

• Dermatology
• Genetics
• Syndromology

Background:

• Triangular lunulae are typically associated with Nail-Patella Syndrome.
• Papillon-Lefèvre syndrome (PLS) is a rare genodermatosis with substantial morbidity.
• Consanguinity is a significant risk factor for rare genetic disorders like PLS.

Purpose of the Study:

• To highlight that triangular lunulae can be indicative of conditions beyond Nail-Patella Syndrome.
• To emphasize the importance of considering PLS in cases presenting with triangular lunulae.
• To underscore the role of consanguinity in the prevalence of PLS.

Main Methods:

• Case presentation of a patient with triangular lunulae.
• Review of literature on nail abnormalities and genodermatoses.
• Analysis of the association between consanguinity and PLS.

Main Results:

• The case demonstrates that triangular lunulae are not exclusive to Nail-Patella Syndrome.
• Papillon-Lefèvre syndrome presents a significant clinical challenge due to its associated morbidity.
• Consanguinity was identified as a key factor contributing to the occurrence of the syndrome in the studied population.

Conclusions:

• Early diagnosis and management are critical for reducing morbidity in patients with PLS.
• Increased societal awareness regarding consanguinity can help mitigate the impact of genetic diseases in affected communities.
• Broadening the differential diagnosis for triangular lunulae is essential for accurate syndromic identification.