Related Experiment Video
Updated: May 8, 2025
10:04
Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
18.7K
Combating TB Pathology: Advanced Diagnostics, Innovative Therapies, and Public Health Strategies: A Review
Satyajit Mohanty1, Manmeet Kaur Khanna2, Krishnendu Adhikary3
1Division of Pharmacology, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi- 835215, Jharkhand, India.
Current Pharmaceutical Biotechnology
|April 16, 2025
Summary
This study reviews advancements in tuberculosis (TB) drug development, including new therapies and repurposed drugs. It highlights innovative strategies like immunotherapy and phytochemicals to accelerate TB treatment and combat resistance.
Area of Science:
- Microbiology
- Pharmacology
- Public Health
Background:
- Tuberculosis (TB) remains a significant global health issue caused by Mycobacterium tuberculosis.
- Effective TB management necessitates advanced diagnostics and novel therapeutic strategies.
- Drug resistance and treatment complexity pose major challenges to TB control.
Purpose of the Study:
- To explore current progress and challenges in anti-TB drug development, particularly those in clinical trials.
- To examine innovative therapeutic approaches, including immunotherapy, combination therapy, and phytochemical adjuncts.
- To assess strategies for accelerating TB treatment and enhancing patient adherence.
Main Methods:
- Review of scientific literature on anti-TB drug development and clinical trials.
- Analysis of emerging therapeutic modalities such as immunotherapy and drug repurposing.
- Examination of adjunct therapies including phytochemicals and public health interventions.
Main Results:
- Several novel anti-TB drugs are in various phases of clinical trials.
- Drug repurposing and combination therapies show promise in overcoming resistance.
- Immunotherapy and phytochemicals offer potential for enhanced treatment efficacy.
Conclusions:
- Innovative approaches are crucial for accelerating TB treatment and overcoming drug resistance.
- Integrated strategies combining novel drugs, adjunct therapies, and public health measures are vital.
- Further research and development are essential to improve global TB control outcomes.
Keywords:
Tuberculosis treatmentadvanced diagnosticscombination therapydrug delivery systemsdrug design and developmentimmunotherapypublic healthvaccines.More Related Videos
Related Concept Videos
01:28Pulmonary Tuberculosis V
145
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
145
01:26Pulmonary Tuberculosis IV
116
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
116
01:28Pulmonary Tuberculosis II
188
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
188
01:29Pulmonary Tuberculosis I
198
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
198
01:26Sputum Studies I: Gram Stain, cytology, and Acid-fast smear and culture
132
Sputum studies are a critical part of diagnosing and treating numerous respiratory conditions. These studies involve obtaining sputum samples for analysis to identify pathogenic organisms and assess the presence of abnormal cells indicative of malignant conditions. This lesson will delve into three fundamental sputum studies: Gram Stain, Cytology, and Acid-fast Smear and Culture.
Gram Stain
The Gram Stain is an integral part of sputum studies. It involves the staining of sputum, which permits...
Gram Stain
The Gram Stain is an integral part of sputum studies. It involves the staining of sputum, which permits...
132
01:31Pulmonary Tuberculosis III
254
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
254