Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Long bone defects treated with demineralized bone.

L E Dahners, R R Jacobs

    Southern Medical Journal
    |August 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A comparison of grafting materials in experimental bone grafts.

    Orthopedics·2014
    Same author

    A cyclooxygenase-2 inhibitor impairs ligament healing in the rat.

    The American journal of sports medicine·2001
    Same author

    Locational uncertainty in georeferencing public health datasets.

    Journal of exposure analysis and environmental epidemiology·2001
    Same author

    The effect of NKISK on tendon in an in vivo model.

    Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2001
    Same author

    The pentapeptide NKISK affects collagen fibril interactions in a vertebrate tissue.

    Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2000
    Same author

    Does the chronic prostatitis/pelvic pain syndrome differ from nonbacterial prostatitis and prostatodynia?

    The Journal of urology·2000
    Same journal

    SMA's 6th Annual Physicians-in-Training Leadership Conference Abstract Presentations.

    Southern medical journal·2026
    Same journal

    Potential Impact of Lower Federal Loan Availability on Medical Education in Appalachia.

    Southern medical journal·2026
    Same journal

    Experiential Mentorship Skills Training: The Effect on Real-Life Mentoring.

    Southern medical journal·2026
    Same journal

    Social Pressure: How Early Social Context Shapes Career Interest in Medicine.

    Southern medical journal·2026
    Same journal

    Comparing Speed and Accuracy of Artificial Intelligence Large Language Models on the Orthopedic In-Training Examination.

    Southern medical journal·2026
    Same journal

    Don't Wait to Talk about Weight: A 2-Hour Interactive Curriculum Improves Medical Student Skills with Weight Management.

    Southern medical journal·2026
    See all related articles

    Demineralized bone alloimplant (DBA) shows excellent osteogenic potential for long bone defects. However, it did not prevent nonunion in this canine ulna defect model.

    Area of Science:

    • Orthopedic surgery
    • Biomaterials science
    • Regenerative medicine

    Background:

    • Long bone defects pose significant challenges in orthopedic treatment.
    • Demineralized bone alloimplant (DBA) is a potential biomaterial for bone regeneration.
    • Cortical autografts (CA) serve as a common bone grafting standard.

    Purpose of the Study:

    • To evaluate the efficacy of demineralized bone alloimplant (DBA) in healing critical-sized long bone defects.
    • To compare the bone healing potential of DBA with cortical autografts (CA).

    Main Methods:

    • Segmental defects (25 mm) were created in the ulnas of seven mongrel dogs.
    • Defects were filled with either demineralized bone alloimplant (DBA) or cortical autograft (CA).
    • Radiographic analysis was performed to quantify bone formation and assess healing.

    Related Experiment Videos

    Main Results:

    • Cortical autograft (CA) defects were filled 139% +/- 11% with bone.
    • Demineralized bone alloimplant (DBA) defects were filled 143% +/- 45% with newly formed bone.
    • No significant difference in bone fill was observed between DBA and CA groups.

    Conclusions:

    • Demineralized bone alloimplant (DBA) acts as a potent osteogenic stimulant.
    • Despite osteogenic potential, DBA did not prevent nonunion in this long bone defect model.
    • Further research is needed to optimize DBA for preventing nonunion in clinical applications.