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Evaluating the Cost-Effectiveness of Chlorhexidine-Coated vs. Standard Peripheral Insertion Central Catheters in

Jia Xu1, Hossein Zare1, Herng-Chia Chiu2

  • 1Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21202, USA.

International Journal of Environmental Research and Public Health
|April 16, 2025
PubMed

Insights

Chlorhexidine-coated (AGBA) peripheral insertion central catheters (PICCs) are more cost-effective than standard PICCs for hematologic patients. AGBA PICCs reduce costs and improve quality-adjusted life years (QALYs), offering significant healthcare savings.

Area of Science:

  • Health Economics
  • Medical Devices
  • Oncology

Background:

  • Catheter-related complications pose significant risks for patients undergoing chemotherapy.
  • Peripheral insertion central catheters (PICCs) are commonly used in hematologic disease management.
  • Assessing the cost-effectiveness of advanced medical devices is crucial for optimizing healthcare resource allocation.

Purpose of the Study:

  • To evaluate the cost-effectiveness of chlorhexidine-coated (AGBA) PICCs compared to standard PICCs.
  • To determine the economic impact of using AGBA PICCs in patients with hematologic diseases.
  • To analyze the impact on quality-adjusted life years (QALYs) and healthcare costs.

Main Methods:

  • A decision tree health economic model was utilized.
  • Data on quality-adjusted life years (QALYs), complication rates, and costs were derived from a randomized controlled trial and literature.
  • Incremental cost-effectiveness ratio (ICER) and sensitivity analyses were performed against willingness-to-pay (WTP) thresholds.

Main Results:

  • AGBA PICCs demonstrated a cost saving of RMB 2291.10 (USD 428.44) per patient compared to standard PICCs.
  • AGBA PICCs were associated with an increase of 0.05 QALYs over 90 days.
  • The incremental cost-effectiveness ratio (ICER) for AGBA PICCs was RMB 4271.31 (USD 629.96).

Conclusions:

  • AGBA PICCs are a cost-effective intervention for managing catheter-related complications in hematologic patients.
  • Sensitivity analyses confirmed the robustness of the findings, supporting AGBA PICCs' economic benefits.
  • Adoption of AGBA PICCs in routine chemotherapy can lead to substantial healthcare savings over a one-year period.
Abstract

Keywords:
ICERcatheter-related complicationchlorhexidine-coated PICCcost-effectiveness analysisone-way sensitivity analyses

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