Clinical Neuroimaging Over the Last Decade: Achievements and What Lies Ahead

The past decade has witnessed notable advancements in clinical neuroimaging facilitated by technological innovations and significant scientific discoveries. In conjunction with Investigative Radiology 's 60th anniversary, this review examines key contributions from the past 10 years, emphasizing the journal's most accessed articles and their impact on clinical practice and research. Advances in imaging technologies, including photon-counting computed tomography, and innovations in low-field and high-field magnetic resonance imaging systems have expanded diagnostic capabilities. Progress in the development and translation of contrast media and rapid quantitative imaging techniques has further improved diagnostic accuracy. Additionally, the integration of advanced data analysis methods, particularly deep learning and medical informatics, has improved image interpretation and operational efficiency. Beyond technological developments, this review highlights basic neuroscience findings, such as the discovery and characterization of the glymphatic system. These insights have provided a deeper understanding of central nervous system physiology and pathology, bridging the gap between research and clinical applications. This review integrates these advancements to provide an overview of the progress and ongoing challenges in clinical neuroimaging, offering insights into its current state and potential future directions within the broader field of radiology.