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Updated: May 13, 2025
Multifocal Electroretinograms
Published on: December 4, 2011
The observation of the foveal granular reflexes with multiple evanescent white dot syndrome
Nozomu Hashiya1, Taiji Hasegawa, Ichiro Maruko
1Department of Ophthalmology, Tokyo Women's Medical University.
Purpose:
To evaluate the foveal granular reflexes (Jampol dots) in macula with multiple evanescent white dot syndrome (MEWDS) and describe the pathophysiology.
Methods:
Eighteen eyes of 18 MEWDS cases (4 male,14 female) were studied. We evaluated the presence and location of Jampol dots and classified them into micro and fused types based on the fundus appearance, and mixed type was included in the fused type. The findings of Jampol dots in optical coherence tomography (OCT) and en face OCT were investigated. A normal 18 eyes were also analyzed.
Results:
Jampol dots seen in (83%) 15 of 18 eyes: micro type in 5 eyes, fused type in 10 eyes. OCT showed more outer retinal damage in the fused type than in the micro type (10 of 10 eyes, 100% vs. 3 of 5 eyes, 60%). En face OCT showed two kinds of findings: hyperreflections in the superficial capillary slab and hyperreflections in the outer retinal slab. The mean visual acuity was worse in the fused type compared to the micro type.
Conclusions:
Jampol dots with MEWDS were classified into two types, and their localization was found to be different. This could be useful in understanding the pathogenesis of MEWDS.
Insights
Foveal granular reflexes, or Jampol dots, in multiple evanescent white dot syndrome (MEWDS) present in two distinct types: micro and fused. The fused type shows greater outer retinal damage and worse visual acuity in MEWDS patients.
Area of Science:
- Ophthalmology
- Retinal Imaging
- Neuro-ophthalmology
Background:
- Multiple evanescent white dot syndrome (MEWDS) is an idiopathic inflammatory condition affecting the outer retina and retinal pigment epithelium.
- Foveal granular reflexes, termed Jampol dots, are a characteristic but poorly understood finding in MEWDS.
Purpose of the Study:
- To evaluate the characteristics and localization of Jampol dots in MEWDS patients.
- To describe the pathophysiology of Jampol dots in relation to MEWDS.
Main Methods:
- Retrospective analysis of 18 eyes from 18 MEWDS patients.
- Classification of Jampol dots into micro and fused types based on fundus appearance.
- Evaluation using optical coherence tomography (OCT) and en face OCT.
Main Results:
- Jampol dots were observed in 83% of MEWDS eyes, classified as micro (5 eyes) or fused (10 eyes).
- The fused type demonstrated more significant outer retinal damage (100%) compared to the micro type (60%) on OCT.
- En face OCT revealed distinct hyperreflective findings in superficial capillary and outer retinal slabs; visual acuity was poorer in the fused type.
Conclusions:
- Jampol dots in MEWDS can be categorized into micro and fused types with differing localizations.
- These classifications may aid in understanding the underlying pathogenesis of MEWDS.
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