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Related Experiment Videos

Pulmonary platelet kinetics in asthma.

P W Ind, A M Peters, F Malik

    Thorax
    |June 1, 1985
    PubMed
    Summary

    This study found no evidence of increased platelet aggregation in the lungs during asthma attacks. Platelet survival remained normal in both asthmatic and non-asthmatic individuals.

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    Area of Science:

    • Pulmonary Medicine
    • Hematology
    • Immunology

    Background:

    • Platelets release bronchoconstrictors, and their activation is linked to allergic asthma.
    • Studies in guinea pigs show pulmonary platelet aggregation during asthma-induced bronchoconstriction.

    Purpose of the Study:

    • To investigate the role of intrapulmonary platelets in human atopic asthma.
    • To determine if platelet accumulation occurs in the lungs during antigen-induced bronchoconstriction.

    Main Methods:

    • Injected radiolabeled autologous platelets (indium-111) and red blood cells (technetium-99m) into asthmatic and non-asthmatic volunteers.
    • Monitored lung and blood radioactivity to calculate pulmonary platelet transit time ratio (tp/tr).
    • Assessed changes in lung signals and tp/tr after bronchial challenge with Dermatophagoides pteronyssinus in asthmatic subjects.

    Main Results:

    • Pulmonary platelet to red cell transit time ratio (tp/tr) did not indicate an intrapulmonary platelet pool in normal subjects.
    • One asthmatic subject showed a slightly prolonged transpulmonary transit time.
    • Antigen challenge in asthmatics caused bronchoconstriction (FEV1 decrease) and small decreases in lung indium-111 signal, but not technetium-99m.
    • tp/tr ratios decreased during bronchoconstriction, arguing against intrapulmonary platelet accumulation.

    Conclusions:

    • Antigen-induced bronchoconstriction in atopic asthma is not accompanied by intrapulmonary platelet accumulation.
    • Platelet survival was normal in both asthmatic and non-asthmatic subjects.
    • The findings do not support a significant role for intrapulmonary platelet pooling in the pathophysiology of acute allergic asthma attacks.

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