Related Experiment Video
Updated: May 12, 2025
Direct Bioprinting of 3D Multicellular Breast Spheroids onto Endothelial Networks
Published on: November 2, 2020
On-orbit 3D bioprinting for tumor modeling in space
Yongcong Fang1, Wenshuai Hao2, Zhuo Xiong3
1Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China; State Key Laboratory of Tribology in Advanced Equipment, Beijing 100084, China; State Key Laboratory of Clean and Efficient Turbomachinery Power Equipment, Beijing, 100084, China; Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing, Beijing 100084, PR China; 'Biomanufacturing and Engineering Living Systems' Innovation International Talents Base (111 Base), Beijing 100084, PR China.
On-orbit 3D bioprinting accurately models space-induced tumor changes, advancing cancer research. This technology promises new insights for developing novel cancer therapies on Earth.
Area of Science:
- Biomedical Engineering
- Space Biology
- Oncology
Background:
- Current 2D and 3D cell models have limitations in replicating complex tumor microenvironments under space conditions.
- Understanding space-induced effects on tumorigenesis is crucial for cancer research.
Purpose of the Study:
- To evaluate the potential of on-orbit 3D bioprinting for accurately modeling tumor environments in space.
- To explore the application of this technology in uncovering space-related regulatory pathways of cancer.
Main Methods:
- Utilizing advanced 3D bioprinting techniques aboard the International Space Station (ISS).
- Culturing and analyzing complex tumor models in microgravity and space radiation environments.
Main Results:
- On-orbit 3D bioprinting provides a more accurate replication of tumor microenvironments compared to traditional cell models.
- Demonstrated feasibility of studying space-induced alterations in cancer biology.
Conclusions:
- On-orbit 3D bioprinting is a promising technology for cancer research in space.
- This approach can accelerate the discovery of novel cancer treatments applicable on Earth.
