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On-orbit 3D bioprinting for tumor modeling in space
Yongcong Fang1, Wenshuai Hao2, Zhuo Xiong3
1Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China; State Key Laboratory of Tribology in Advanced Equipment, Beijing 100084, China; State Key Laboratory of Clean and Efficient Turbomachinery Power Equipment, Beijing, 100084, China; Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing, Beijing 100084, PR China; 'Biomanufacturing and Engineering Living Systems' Innovation International Talents Base (111 Base), Beijing 100084, PR China.
Abstract:
On-orbit 3D bioprinting offers a more accurate replication of complex tumor environments under space conditions than current 2D and 3D cell models. This technology holds great promise for uncovering regulatory pathways of tumorigenesis and tumor suppression in space, thus accelerating the development of innovative cancer treatments on Earth.
Insights
On-orbit 3D bioprinting accurately models space-induced tumor changes, advancing cancer research. This technology promises new insights for developing novel cancer therapies on Earth.
Area of Science:
- Biomedical Engineering
- Space Biology
- Oncology
Background:
- Current 2D and 3D cell models have limitations in replicating complex tumor microenvironments under space conditions.
- Understanding space-induced effects on tumorigenesis is crucial for cancer research.
Purpose of the Study:
- To evaluate the potential of on-orbit 3D bioprinting for accurately modeling tumor environments in space.
- To explore the application of this technology in uncovering space-related regulatory pathways of cancer.
Main Methods:
- Utilizing advanced 3D bioprinting techniques aboard the International Space Station (ISS).
- Culturing and analyzing complex tumor models in microgravity and space radiation environments.
Main Results:
- On-orbit 3D bioprinting provides a more accurate replication of tumor microenvironments compared to traditional cell models.
- Demonstrated feasibility of studying space-induced alterations in cancer biology.
Conclusions:
- On-orbit 3D bioprinting is a promising technology for cancer research in space.
- This approach can accelerate the discovery of novel cancer treatments applicable on Earth.
