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Updated: May 11, 2025

Performing Spectroscopy on Plasmonic Nanoparticles with Transmission-Based Nomarski-Type Differential Interference Contrast Microscopy
Published on: June 5, 2019
Vibrational circular dichroism of plasmonic nanostructures embedding chiral drugs
Raju Adhikary1, Matteo Venturi1, Giovanna Salvitti1
1Department of Physical and Chemical Sciences, University of L'Aquila, Via Vetoio, 67100, L'Aquila, Italy.
Abstract:
We investigate the mid-infrared chiroptical response of plasmonic nanostructures based on Al-doped ZnO and layers of an aqueous solution of Ladarixin, a chiral pharmaceutical currently under clinical trial for the treatment of type 1 diabetes. We explore the possibilities offered by localised surface plasmon resonances (LSPRs) for the enhancement of vibrational circular dichroism (VCD) of the considered chiral drug solution. Focusing on diverse plasmonic nanoshell geometries, we find that LSPRs provide an amplification factor of VCD differential absorption cross-section ranging from [Formula: see text] to [Formula: see text] thanks to near-field intensity enhancement produced by LSPRs. Our results indicate that nanoshell LSPRs are promising for probing molecular chirality at the nanoscale.
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