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[Association between insulin resistance and uterine volume in girls with idiopathic central precocious puberty]

Hong-Ru Zhang1, Ya Xiao1, Shu-Qin Jiang1

  • 1Department of Pediatrics, Third Affiliated Hospital of Zhengzhou University/Henan Maternal and Child Health Hospital, Zhengzhou 450052, China.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|April 17, 2025
PubMed

Insights

Girls with idiopathic central precocious puberty (ICPP) show higher insulin resistance and uterine volume. Increased insulin resistance is linked to larger uterine volume in these girls.

Area of Science:

  • Pediatric endocrinology
  • Reproductive health
  • Metabolic disorders

Context:

  • Idiopathic central precocious puberty (ICPP) involves early puberty onset.
  • Insulin resistance is a metabolic condition affecting glucose regulation.
  • Uterine volume can be an indicator of reproductive development.

Purpose:

  • To examine the relationship between insulin resistance and uterine volume in girls with ICPP.
  • To compare these metrics between girls with ICPP and healthy controls.

Summary:

  • Girls with ICPP exhibited significantly higher uterine volume and homeostasis model assessment of insulin resistance (HOMA-IR) compared to controls.
  • A positive correlation was found between HOMA-IR and uterine volume in the ICPP group.
  • Increased HOMA-IR was associated with increased uterine volume in girls with ICPP.

Impact:

  • Highlights a potential link between metabolic dysfunction and reproductive organ development in precocious puberty.
  • Suggests that insulin resistance may play a role in the uterine changes observed in ICPP.
  • Informs potential therapeutic strategies targeting metabolic health in ICPP management.
Abstract

Keywords:
ChildHypothalamic-pituitary- gonadal axisIdiopathic central precocious pubertyInsulin resistanceUterine volume

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