Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fractures: Bone Repair01:27

Fractures: Bone Repair

2.8K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
2.8K
Bone Disorders01:29

Bone Disorders

3.3K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.3K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

209
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
209
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

3.6K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
3.6K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

3.1K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.1K
Bone Remodeling01:40

Bone Remodeling

38.0K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preventing post-denosumab bone loss with zoledronate: a 2-year randomized trial in post-menopausal women without and with pre-exposure to bisphosphonates.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
Same author

Intravascular lithotripsy for coral reef aortic stenosis: a case series assessing feasibility, hemodynamic effects, imaging and clinical outcomes.

CVIR endovascular·2026
Same author

Insulin therapy improves bone microstructure and material properties without restoring whole-bone strength in male insulin-deficient Akita mice.

Bone·2026
Same author

The gut-bone axis: microbial metabolism and nutritional interventions for bone health.

Gut microbes·2026
Same author

Consensus statement on the application of artificial intelligence in osteoporosis screening and management: perspectives from the Asia-Pacific region.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
Same author

Orthogeriatric Fracture Syndrome: A Large-Scale Bibliometric Analysis of a Proposed Concept for Cross-Disciplinary Awareness and Coordinated Care.

Journal of clinical medicine·2026

Related Experiment Video

Updated: May 11, 2025

Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis
02:08

Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis

Published on: July 5, 2024

595

[Bone fragility management in diabetic patients].

Emmanuel Biver1, Maria Papageorgiou1, Serge Ferrari1

  • 1Service des maladies osseuses, Département de médecine, Hôpitaux universitaires de Genève et Faculté de médecine, 1211 Genève 14.

Revue Medicale Suisse
|April 17, 2025
PubMed
Summary

Diabetes increases fracture risk, particularly in type 2, where bone density and FRAX scores may underestimate danger. Poor glycemic control is a key predictor, necessitating tailored fracture prevention strategies.

More Related Videos

A Simple Critical-sized Femoral Defect Model in Mice
09:41

A Simple Critical-sized Femoral Defect Model in Mice

Published on: March 15, 2015

15.0K
The Generation of Closed Femoral Fractures in Mice: A Model to Study Bone Healing
05:53

The Generation of Closed Femoral Fractures in Mice: A Model to Study Bone Healing

Published on: August 16, 2018

15.1K

Related Experiment Videos

Last Updated: May 11, 2025

Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis
02:08

Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis

Published on: July 5, 2024

595
A Simple Critical-sized Femoral Defect Model in Mice
09:41

A Simple Critical-sized Femoral Defect Model in Mice

Published on: March 15, 2015

15.0K
The Generation of Closed Femoral Fractures in Mice: A Model to Study Bone Healing
05:53

The Generation of Closed Femoral Fractures in Mice: A Model to Study Bone Healing

Published on: August 16, 2018

15.1K

Area of Science:

  • Endocrinology
  • Metabolic disorders
  • Bone health

Context:

  • Type 1 and type 2 diabetes are associated with an elevated risk of fractures.
  • Bone mineral density (BMD) shows differing trends in type 1 (decreased) versus type 2 (increased) diabetes.
  • Established fracture risk assessment tools like FRAX may underestimate risk in type 2 diabetes patients.

Purpose:

  • To highlight the complex relationship between diabetes and fracture risk.
  • To identify key predictors of fracture in diabetic populations.
  • To discuss management considerations for osteoporosis and fracture prevention in diabetic patients.

Summary:

  • Fracture risk is elevated in both type 1 and type 2 diabetes.
  • Poor glycemic control is the primary predictor of fractures in diabetic individuals.
  • While standard osteoporosis treatments can be used cautiously in high-risk diabetic patients, fall prevention and muscle health optimization are crucial, especially for older adults.

Impact:

  • This research underscores the need for specialized fracture risk assessment in diabetic patients, particularly those with type 2 diabetes.
  • It emphasizes the critical role of glycemic control in mitigating fracture risk.
  • Findings inform clinical practice by suggesting targeted interventions for fracture prevention in this vulnerable population.