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Palmitoylation in cardiovascular diseases: Molecular mechanism and therapeutic potential

Rongli Wang1,2, Yi He1,2, Yan Wang1,2,3,4

  • 1Division of Cardiology, Departments of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China.

International Journal of Cardiology. Heart & Vasculature
|April 17, 2025
PubMed

Insights

Palmitoylation, a protein modification, significantly impacts cardiovascular disease progression by altering protein function. Targeting this process offers a potential new therapeutic strategy for heart conditions.

Area of Science:

  • Biochemistry and Molecular Biology
  • Cardiology
  • Pathophysiology

Background:

  • Cardiovascular diseases (CVDs) are a major global cause of mortality.
  • Protein post-translational modifications are critical in CVD development.
  • Palmitoylation is a key lipid modification influencing protein function in CVDs.

Purpose of the Study:

  • To review recent advancements in understanding protein palmitoylation in cardiovascular diseases.
  • To explore the role of palmitoylation in CVD pathophysiology.
  • To discuss palmitoylation as a potential therapeutic target for CVDs.

Main Methods:

  • Narrative review of existing literature.
  • Analysis of studies on protein palmitoylation in cardiovascular contexts.
  • Synthesis of findings on the impact of palmitoylation on protein stability, localization, and signaling.

Main Results:

  • Palmitoylation enhances protein hydrophobicity, affecting cardiovascular proteins.
  • This lipidation influences critical pathophysiological processes including metabolism and inflammation.
  • Altered protein stability, localization, and signal transduction are key consequences of palmitoylation.

Conclusions:

  • Palmitoylation is a significant factor in the pathophysiology of cardiovascular diseases.
  • Understanding protein palmitoylation provides insights into disease mechanisms.
  • Targeting protein palmitoylation presents a promising avenue for novel cardiovascular therapies.

Keywords:
Cardiovascular diseasesPalmitoylationPost-translational modificationszDHHC

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