Related Experiment Video
Updated: May 11, 2025
10:03
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
5.2K
Systemic inflammation-based Glasgow Prognostic Score as a prognostic indicator in chronic heart failure
Shigeto Namiuchi1, Kotaro Nochioka2, Ryoichi Ushigome3
1Department of Cardiology, Sendai City Medical Center, Sendai Open Hospital, Sendai, Japan.
International Journal of Cardiology. Heart & Vasculature
|April 17, 2025
Summary
The Glasgow Prognostic Score (GPS) effectively predicts long-term mortality risk in patients with chronic heart failure (HF). Higher GPS scores, indicating greater systemic inflammation, correlate with significantly increased mortality.
Area of Science:
- Cardiology
- Inflammation Biomarkers
- Prognostic Indicators
Background:
- The Glasgow Prognostic Score (GPS) is established for predicting outcomes in cancer and acute heart failure.
- Chronic heart failure (HF) management requires reliable prognostic tools.
Purpose of the Study:
- To investigate the association between the Glasgow Prognostic Score (GPS) and long-term mortality in patients with chronic heart failure (HF).
Main Methods:
- A large, multicentre prospective observational study (CHART-2) included 6,480 patients with chronic HF.
- GPS was calculated based on C-reactive protein and serum albumin levels.
- Mortality data was collected over a median follow-up of 9.62 years.
Main Results:
- A total of 2,564 patients (39.6%) died during follow-up.
- Increased GPS was significantly associated with higher all-cause mortality risk (log-rank P < 0.0001).
- Adjusted analyses confirmed elevated hazard ratios for mortality with GPS scores of 1 and 2, independent of B-type natriuretic peptide levels.
Conclusions:
- The Glasgow Prognostic Score (GPS) serves as a valuable predictor of long-term prognosis in chronic heart failure (HF) patients.
- GPS reflects systemic inflammation and aids in risk stratification for chronic HF.
Related Concept Videos
01:17Pathophysiology of Heart Failure
1.4K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.4K
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
38
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
38