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Related Concept Videos

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
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Related Experiment Video

Updated: May 11, 2025

Performing and Processing FNA of Anterior Fat Pad for Amyloid
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Colovesical Fistula and Amyloidosis.

Samantha Leng1, Wei Ming Ong1, Reizal Mohd Rosli1

  • 1Colorectal Surgery, Eastern Health, Melbourne, AUS.

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|April 17, 2025
PubMed
Summary

Systemic amyloidosis involves toxic protein buildup, damaging organs. This case highlights immunoglobulin G kappa amyloid light chain amyloidosis causing a rare colovesical fistula.

Keywords:
gastrointestinal amyloidhartmann's procedureimmunoglobulin light chain amyloidosissystemic amyloidosisvesicocolic fistula

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Area of Science:

  • Medicine
  • Pathology
  • Gastroenterology

Background:

  • Systemic amyloidosis is characterized by toxic, insoluble beta-sheet fibrillar protein deposition in extracellular tissues.
  • This deposition can damage multiple organ systems, including the gastrointestinal tract, leading to manifestations like bleeding and diarrhea.
  • Amyloid proteins such as transthyretin, light chains, and serum amyloid A are implicated in these pathological processes.

Observation:

  • A case study involving a 71-year-old male patient is presented.
  • The patient was diagnosed with systemic immunoglobulin G kappa amyloid light chain amyloidosis.
  • The patient developed a colovesical fistula, a rare complication.

Findings:

  • The colovesical fistula in this case was directly related to amyloid deposition.
  • This finding underscores the potential for amyloidosis to cause unusual and severe gastrointestinal complications.
  • Immunoglobulin G kappa amyloid light chain amyloidosis can manifest with complex anatomical fistulas.

Implications:

  • This case expands the understanding of the diverse clinical manifestations of systemic amyloidosis.
  • It highlights the importance of considering amyloidosis in patients presenting with unexplained gastrointestinal issues, including fistulas.
  • Further research into the mechanisms of amyloid deposition in the gastrointestinal tract may lead to improved diagnostic and therapeutic strategies.