Childhood mastocytosis: challenges and potential shortfalls in current disease classification

The skin is the organ most frequently involved in childhood mastocytosis. In this article, we present a comprehensive update on recent relevant data in the field of childhood mastocytosis, and critically review the drawbacks of its current classification and skin manifestations. We hypothesize that two main types of childhood mastocytosis can be recognized, with relevant implications for the outcome, management and understanding of the disease.