Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serum Proteomic Profiling Implicates a Dysregulated Neurohormonal-Inflammatory Axis in Post-Fontan Sinus Tachycardia.

Journal of the American Heart Association·2026
Same author

Mechanics and mechanobiology of arterial development.

Biomechanics and modeling in mechanobiology·2026
Same author

Postnatal pulmonary artery development from transcript to tissue.

Journal of the Royal Society, Interface·2026
Same author

MRI-Based Pressure Gradient Mapping in Patient-Specific Models of Coarctation of the Aorta.

medRxiv : the preprint server for health sciences·2026
Same author

Impact of guideline definitions on right ventricular diameter in echocardiography: an automated analysis in controls and patients with pulmonary hypertension.

Echo research and practice·2026
Same author

SDFStent: Real-time interactive virtual stenting via SDF deformation fields.

ArXiv·2026

Related Experiment Video

Updated: May 11, 2025

Author Spotlight: Improved Imaging for Neovascular Development in Congenital Heart Disease Research
07:53

Author Spotlight: Improved Imaging for Neovascular Development in Congenital Heart Disease Research

Published on: April 26, 2024

461

Oversized Conduits Predict Stenosis in Tissue Engineered Vascular Grafts.

Kevin M Blum1, Mackenzie E Turner2, Erica L Schwarz3

  • 1Center for Regenerative Medicine, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA; Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA.

JACC. Basic to Translational Science
|April 17, 2025
PubMed
Summary

Tissue-engineered vascular grafts (TEVGs) show promise for congenital heart disease. Proper graft sizing matching native vessels is crucial to prevent stenosis and improve TEVG performance.

Keywords:
computational fluid dynamicsoversizingstenosistissue engineered vascular graft

More Related Videos

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
13:04

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Published on: March 18, 2015

11.9K
Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method
09:38

Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method

Published on: March 27, 2017

8.3K

Related Experiment Videos

Last Updated: May 11, 2025

Author Spotlight: Improved Imaging for Neovascular Development in Congenital Heart Disease Research
07:53

Author Spotlight: Improved Imaging for Neovascular Development in Congenital Heart Disease Research

Published on: April 26, 2024

461
Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
13:04

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Published on: March 18, 2015

11.9K
Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method
09:38

Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method

Published on: March 27, 2017

8.3K

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Cardiovascular Research

Background:

  • Tissue-engineered vascular grafts (TEVGs) offer a solution for congenital heart disease repair using autologous tissue.
  • Current TEVG strategies involve biodegradable scaffolds seeded with cells to form functional neovessels.
  • Understanding factors influencing neovessel formation is critical for optimizing TEVG efficacy.

Purpose of the Study:

  • To identify key factors influencing neovessel formation and stenosis development in thoracic TEVGs.
  • To evaluate the impact of hemodynamics and surgical sizing on TEVG outcomes.
  • To correlate preclinical findings with clinical data for improved TEVG design.

Main Methods:

  • Evaluation of 50 ovine thoracic TEVGs using angiography at 1 and 6 weeks postimplantation.
  • Nondimensionalization to account for anatomical variations and analyze hemodynamics.
  • Regression analysis and computational fluid dynamics (CFD) to assess graft narrowing and wall shear stress.

Main Results:

  • Narrowing at the inflow anastomosis and graft oversizing were significantly correlated with stenosis development.
  • CFD analysis indicated that these factors alter wall shear stress and flow patterns, leading to neovessel narrowing.
  • Findings were supported by comparisons with clinical data from Fontan conduit trials.

Conclusions:

  • Surgical sizing and inflow hemodynamics are critical determinants of TEVG performance.
  • Matching TEVG size to the native inflow vessel is essential for reducing stenosis.
  • Optimizing graft sizing can enhance the clinical success of TEVGs in treating congenital heart disease.