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Updated: May 11, 2025

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds
Published on: August 21, 2021
Antibacterial Properties of Polymeric Membranes Containing Doxycycline for Potential Applications in Foot Ulcer
Stevaly Pérez-Gutiérrez1, Jesús Ángel Ramírez-Enciso1, Laura Abisai Pazos-Rojas2,3
1Faculty of Medicine, Meritorious Autonomous University of Puebla (BUAP), Puebla 72410, Mexico.
Abstract:
Membranes made from biopolymers and loaded with doxycycline were investigated for potential use in the treatment of foot ulcers in diabetic patients. Carboxymethylcellulose (CMC) and chitosan (CHS) membranes were fabricated with 7% glycerol and 1% doxycycline (DOX). Their mechanical and physical properties, biocompatibility, and antimicrobial effects were thoroughly evaluated. The results demonstrated effective antibacterial activity against S. aureus and S. mutans. Based on the mechanical, physical, and hemolytic data, DOX-loaded CMC/CHS/G membranes show promise as a topical wound delivery system.
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