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Related Concept Videos

Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

26
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
26
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

906
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
906
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

30
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
30
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

563
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
563
The Oral Microbiota01:27

The Oral Microbiota

90
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
90
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

46
The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
46

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Updated: May 5, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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Periodontitis and Pancreatic Cancer Risk: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis.

Kareelend Andreina Segura Cueva1, Andrea Bermúdez Velásquez2, Carlos Andrés Guim Martínez2

  • 1College of Dentistry, University of Guayaquil, Guayaquil 090101, Ecuador.

Journal of Clinical Medicine
|May 4, 2026
PubMed
Summary
This summary is machine-generated.

Periodontitis, a gum disease, is linked to a modest increase in pancreatic cancer risk. However, the absolute risk is small, and more research is needed to confirm causality.

Keywords:
inflammationpancreatic neoplasmsperiodontitisrisk factorstooth loss

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Area of Science:

  • Oncology
  • Periodontology
  • Epidemiology

Background:

  • Pancreatic cancer is a leading cause of cancer death globally.
  • Periodontitis, a common chronic inflammatory condition, is increasingly studied for its systemic health implications.
  • Existing evidence on periodontitis and pancreatic cancer risk is limited and inconsistent.

Purpose of the Study:

  • To systematically review and meta-analyze observational studies.
  • To assess the association between periodontitis and pancreatic cancer risk.

Main Methods:

  • Comprehensive literature search across major databases (PubMed, EMBASE, etc.) following PRISMA guidelines.
  • Inclusion of cohort, case-control, and cross-sectional studies reporting pancreatic cancer risk.
  • Meta-analysis using random-effects models, supplemented by meta-regression and Trial Sequential Analysis (TSA).

Main Results:

  • Eight studies (n=476,245) were included.
  • A modest association was found between periodontitis and increased pancreatic cancer risk (pooled HR=1.56; 95% CI: 1.28-1.89).
  • Trial Sequential Analysis indicated insufficient cumulative evidence for definitive conclusions.

Conclusions:

  • Observational data suggest a statistical link between periodontitis and pancreatic cancer.
  • The absolute increase in risk is minimal.
  • Further large-scale prospective studies with standardized assessments are necessary to establish causality and inform clinical practice.