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Does Optilume drug-coated balloon dilation compromise female sphincter function?
Lukas Andrius Jelisejevas1, Gennadi Tulchiner2, Patricia Kink2
1Department of Urology, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria. lukas.jelisejevas@i-med.ac.at.
International Urology and Nephrology
|April 17, 2025
Summary
Optilume drug-coated-balloon (DCB) dilation offers a promising solution for female urethral strictures, showing high success rates and preserving urinary continence. This minimally invasive approach avoids repeat interventions in most patients, improving quality of life.
Area of Science:
- Urology
- Minimally Invasive Surgery
Background:
- Female urethral strictures (FUS) are uncommon but significantly impact quality of life.
- Recurrent strictures often necessitate complex surgical reconstruction.
- Drug-coated-balloon (DCB) technology presents a novel therapeutic option.
Purpose of the Study:
- To evaluate the efficacy and safety of Optilume DCB dilation for treating female urethral strictures.
- To assess outcomes including anatomical success, recurrence rates, and urinary continence.
- To determine the potential of DCB dilation as an alternative to urethroplasty.
Main Methods:
- A prospective study included 14 female patients with FUS undergoing DCB dilation.
- Diagnosis confirmed by catheterization, ultrasound, or VCUG; exclusion criteria applied.
- DCB dilation performed to 30Fr at 10 bar for 10 minutes, followed by catheterization for 2-5 days.
Main Results:
- 11 of 12 patients (91.7%) remained free from recurrence and repeat intervention at 6 months.
- Mean follow-up was 12 months; mean prior interventions were 4.3.
- All patients maintained urinary continence, with two experiencing improved pre-existing incontinence.
Conclusions:
- Optilume DCB dilation is a safe and well-tolerated short-term treatment for FUS.
- The procedure demonstrates high efficacy in preventing recurrence and repeat interventions.
- Importantly, DCB dilation preserves vital sphincter function.
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