Gut and Joint Microbiomes: Implications in Osteoarthritis
Honey Hendesi1, David A Villani1, Janne Prawitt2
1Department of Orthopedics, University of Colorado, Anschutz Medical Campus, 12800 East 19th Avenue, RC1N, MS8343, Aurora, CO 80045, USA.
None:
This review summarizes and discusses key recent findings suggesting that microbiomes can play a role in the development and progression of osteoarthritis. Evidence supporting a gut microbiome-joint connection derived from human and animal studies is enumerated and discussed, with particular attention on the microbial and molecular basis for the development of therapeutic interventions that involve targeting the gut. Additionally, clinical data supporting the concept of a living microbiome within a diarthrodial joint are summarized. A discussion of key limitations in the current data and important technical considerations for firmly establishing the existence of a synovial joint microbial community is included.
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